Bupropion XL (generic for Wellbutrin XL®)

Bupropion is special or "atypical" antidepressant medication. Technically, it is an aminoketone and norepinephrine-dopamine reuptake inhibitor (NDRI). Notably, Bupropion was the first modern antidepressant on the market (ahead of Prozac and the serotonin reuptake inhibitors or SSRIs), first FDA-approved in 1985 and later in 1989 as an extended-release (XL) formula. Bupropion is sold under the brand names Wellbutrin XL, Wellbutrin SR (sustained release), Aplenzin and Zyban. Bupropion is a prescription medication.

Bupropion hydrochloride is FDA approved to treat major depressive disorder (MDD), among other indications.

The action of Bupropion is relatively complex, affecting the balance of three neurotransmitter chemicals in the brain. Specifically, bupropion inhibits the absorption of dopamine, serotonin, and norepinephrine (aka noradrenaline), which results in more of these chemicals to transmit messages to other nerves in the brain.

Consultation with a psychiatrist or other qualified psychiatry provider online through our platform. If prescribed Bupropion, genuine bupropion xl will be shipped to you discreetly at the cadence you choose. You’ll have ongoing check-ins with a healthcare provider to evaluate whether your treatment plan is working.

The most common side effects of bupropion include feeling anxious, stuffy nose, dry mouth, trouble sleeping, dizziness, nausea, constipation, and joint aches. Less commonly, high blood pressure may manifest as a serious side effect.

Seizure disorder or taking drugs that lower the seizure threshold (eg, antipsychotics, antidepressants, theophylline or corticosteroids) are both well documented bupropion risks. Risk of hypertension is increased if bupropion is used along with MAOIs. This list is not exhaustive. Prepare to share with your healthcare provider your health history and list all prescription and over-the-counter medicines and other products you take.