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Terms & Conditions

Sertraline PEJ Treatment Plan

This treatment plan contains information regarding the medication that was prescribed to you including but not limited to: ingredient information, interactions, side effects, instructions for use, and other important information you should know prior to starting it.

Treatment Plan - Sertraline

Overview

Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of serotonin in the brain. Sertraline is used to treat many conditions including the following; depression, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder, posttraumatic stress disorder, social anxiety disorder and off-label treatment of premature ejaculation.

Serotonin is a natural substance made by nerves. Though the exact cause of premature ejaculation is not known, serotonin may play a role. High amounts of serotonin in the brain increase the time to ejaculation. Low amounts can shorten the time to ejaculation, and lead to premature ejaculation. Healthcare providers noticed that men and women on antidepressants have delayed orgasms. Healthcare providers began to use these drugs "off-label" (for a different reason than the drug's FDA-approved use) to treat premature ejaculation.

Drugs for premature ejaculation can be taken every day or only as needed before sex. With the daily option, there is no need to manage the 4-8 hour lead time before sexual activity, which is required with the ‘as needed’ option.

This medicine is available only with your healthcare provider's prescription and should be taken exactly as directed. It is very important that your primary care provider knows you are taking Sertraline. Do not stop taking this medication without notifying your primary care provider.

Proper Use of This Medication

This medicine must be taken only as directed. Make sure all your healthcare providers are aware that you are taking Sertraline. Do not take more of it, do not take it more often, and do not take it for a longer time than your healthcare provider ordered. Do not change the dose without notifying your healthcare provider. Do not stop taking this medication without notifying your primary care provider.

Before taking any other medications, make sure your healthcare provider is aware of all other medications and supplements you are taking. When taking other medications with this medication, you should notify your healthcare provider if you develop headaches, nausea, sweating, change in mood or behavior, dizziness or confusion.

This medicine should come with a Medication Guide. It is important that you read and understand this information. Ask your healthcare provider about anything you do not understand.

The medication may be taken with or without food. Do not eat grapefruit or drink grapefruit juice while on this medication.

Dosing of As Needed Sertraline for Premature Ejaculation

If determined to be appropriate for you, the healthcare providers providing care through the Hims platorm recommend a single Sertraline 50mg tablet to be taken 4-8 hours before sex. This medication may be taken with or without food. It is very important that your primary care provider knows you are taking Sertraline.

You will be required to have periodic online visits with a provider on our platform to continue receiving your prescription.

Dosing for Patients Switching from As Needed to Daily Sertraline

If determined appropriate for you, the healthcare providers the healthcare providers providing care through the Hims platform recommend a daily dose of Sertraline 50mg to be taken every day at the same, convenient time every day. This medication may be taken with or without food. It is very important that your primary care provider knows you are taking Sertraline. Do not stop taking this medication without notifying your primary care provider.

Dosing of Daily Sertraline for Premature Ejaculation

If determined to be appropriate for you, the healthcare providers providing care through the Hims platform recommend an initial daily dose of Sertraline 25mg to be taken every day for the first month. Take the medication at the same, convenient time every day. This medication may be taken with or without food. It is very important that your primary care provider knows you are taking Sertraline.

You will increase your daily dose to 50mg for the next two months. Continue to take Sertraline at the same, convenient time every day. You will be required to have an online visit with a provider on our platform after 3 months to receive a refill. You should contact the doctor if you are having any changes in mood or behavior.

This medication may be taken with or without food. It is very important that your primary care provider knows you are taking Sertraline. Do not stop taking this medication without notifying your primary care provider.

Use & Storage of Sertraline

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Keep from freezing.
  • Keep out of the reach of children and do not allow other people to take your medication.
  • Do not keep outdated medicine or medicine no longer needed.
  • Ask your healthcare provider how you should dispose of any medicine you do not use.
  • It is very important that your primary care provider knows you are taking Sertraline.
  • Do not stop taking this medication without notifying your primary care provider.

Before using Sertraline for Premature Ejaculation

When deciding to use any medication, the benefits of use must outweigh the risks of use. This is a decision you and your healthcare provider will make together. For this medication, the following should be considered:

Allergies: Do not take this medication if you are allergic to it, or any of its ingredients. Tell your healthcare provider if you have any allergies including medication, food, dyes, preservatives, environmental, or animal. Tell your healthcare provider if you have ever had an unusual reaction to this medicine or any other medicines.

Older Population: Elderly patients may be more sensitive to the effects of this medicine and are more likely to have hyponatremia (low sodium in the blood), which may require caution and an adjustment in the dose.

Drug Interactions with Sertraline: It is very important that your healthcare provider is aware of all medications and supplements you are taking. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Sertraline use is contraindicated and should not be used for patients:

  • with known hypersensitivity/allergy to Sertraline or any of its ingredients
  • taking, or discontinuing MAOIs in the last 14 days (i.e. selegiline, moclobemide, linezolid, methylene blue)
  • taking Pimozide
  • taking the antiretroviral medication Aptivus® (tipranavir)

Your healthcare provider may decide not to treat you with this medication or change some of the other medicines you take. Sertraline should be used with caution in patients:

  • taking other serotonergic drugs (i.e. other SSRIs, SNRIs, MAOIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John’s Wort)
  • taking alpha blockers (i.e. Coreg® (carvedilol), Flomax® (tamsulosin), Hytrin® (terazosin), Minipress® (prazosin))
  • taking anticoagulants (i.e. warfarin, aspirin, nonsteroidal anti-inflammatory drugs)
  • taking drugs that prolong QTc interval (i.e. quinidine, procainamide, sotalol, amiodarone, dronedarone, methadone, levofloxacin, quinine)
  • taking phenytoin
  • taking sildenafil (Revatio®)
  • taking disulfiram (Antibuse®) - with Sertraline oral solution only
  • taking the following antiretroviral medications; Norvir® (ritonavir), Lexiva®, Viracept®, Crixivan®, Reyataz®, Evotaz®, Invirase®, Kaletra®, darunavir/ritonavir (DVR/r), atazanavir/ritonavir (ATV/r), Sustiva® (efavirenz)

Other Interactions

Alcohol use while on Sertraline should be avoided or limited while using this medication. Alcohol may increase the side effects of this medication, such as difficulty concentrating and lethargy. It is very important that your primary care provider knows you are taking Sertraline.

If you are uncertain about the possibility of a drug interaction with Sertraline please consult with your healthcare provider.

Important Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your healthcare provider if you have any other medical problems, especially:

  • Bipolar disorder (mood disorder and depression) (including risk for or history of)
  • Bleeding problems
  • Cardiac or heart problems, circulatory problems
  • Diabetes
  • Glaucoma, angle-closure (including history of), other eye problems
  • HIV
  • Hyponatremia (low sodium in the blood)
  • Liver disease
  • Mania or hypomania (including history of)
  • Multiple sclerosis or similar disease
  • Neurological disease, or spinal injury or paralysis
  • Kidney transplant, or other kidney problem
  • Peyronie’s disease, or other penile problems
  • Purpura (purplish or brownish-red discoloration of the skin) (including history of)
  • Schizophrenia (including history of)
  • Seizures (including history of)—Use with caution, may worsen condition.
  • Sickle cell anemia, myeloma, or leukemia
  • Surgery or radiation to the prostate or pelvis
  • Stroke or severe inefficiency of the autonomic nervous system
  • Ulcers of the stomach, or intestinal ulcers

Special Precautions

  • MAO Inhibitors: Do not take Sertraline with a monoamine oxidase (MAO) inhibitor (i.e. selegiline, moclobemide, linezolid, methylene blue). Do not start taking Sertraline during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping Sertraline before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, rapid heart rate and high blood pressure, heavy sweating, muscle rigidity, and diarrhea. If any of these symptoms occur, contact your healthcare provider. Tell your healthcare provider if you are currently taking an MAOI.
  • Serotonin Syndrome: Patients on Sertraline should be monitored for the emergence of a potentially life-threatening serotonin syndrome, particularly with concomitant use of serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John’s Wort) and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). If concomitant use of Sertraline with other serotonergic drugs is clinically warranted, inform patients of the increased risk of serotonin syndrome and monitor for symptoms. Check with your healthcare provider first before taking any other medicines with Sertraline.
  • Suicidal Ideation: For some young adults, this medicine can increase suicidal thoughts and behavior, especially during the first few months of therapy and with dose changes. Tell your healthcare provider immediately if you start to feel depressed or if you have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure the healthcare provider knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the healthcare provider if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the healthcare provider know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • Bleeding Problems: Sertraline may increase your risk for bleeding problems. Make sure your healthcare provider knows if you are also using other medicines that thin the blood, such as aspirin, NSAID pain or arthritis medicines, warfarin (Coumadin®), or other drugs that affect coagulation.
  • Hyponatremia: This medicine may cause hyponatremia (low sodium in the blood). This is more common in elderly patients, those who are taking diuretic medicines for high blood pressure, or those who have decreased amounts of fluid in the body due to severe diarrhea or vomiting. Check with your healthcare provider right away if you have headache, trouble concentrating, memory problems, confusion, weakness, or unsteadiness.
  • Diabetes: This medicine may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, talk with your healthcare provider.
  • Erectile Dysfunction: Patients who experience erectile dysfunction once starting this medication, should stop the Sertraline for a period of time before starting treatment for erectile dysfunction.
  • Side Effects: This medicine may cause some people to become drowsy, to have trouble thinking, or to have problems with movement. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or well-coordinated.
  • Before you have any medical tests, tell the medical healthcare provider in charge that you or are taking this medicine. The results of some tests may be affected by this medicine.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

To learn more about Sertraline we recommend accessing the Prescribers Digital Reference (PDR).