Provided by You Health

Buspirone (BuSpar®)

Do not take Buspirone if you:
  • are allergic to buspirone, or any of the ingredients in buspirone
  • have severe liver or kidney problems
  • have benzodiazepine dependence
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking and MAOI in the last 14 days including isocarboxazid, phenelzine, rasagiline, selegiline, tranylcypromine
  • take other medication that may cause an increase in serotonin levels such as linezolid, methylene blue, tryptophan
Buspirone can cause serious side effects. Rarely reported side effects include:
  • Chest pain
  • Restlessness or an inability to remain still
  • Involuntary or uncontrolled movements of the body
  • Hostility or depression
  • Rash, hives, swelling, or trouble breathing
  • Serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)
Before you take buspirone, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • drink alcohol or use/abuse recreational or prescription drugs
  • are pregnant, plan to become pregnant, or are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Until you experience how this medication affects you, do not drive a car, operate potentially dangerous machinery, or perform other dangerous activities.
You should take buspirone consistently, either always with or always without food.
During your treatment with buspirone, avoid drinking large amounts of grapefruit juice.
Avoid drinking alcoholic beverages while taking this medication.

Buspirone may affect the way other medicines work, and other medicines may affect the way buspirone works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • Psychotropic agents, including haloperidol (Haldol®)
  • Certain antihypertensives: diltiazem (Cardizem®, Cartia®, Tiazac®) or verapamil (Calan®, Isoptin SR®, Verelan®)
  • Erythromycin
  • Certain antifungals including itraconazole or ketoconazole
  • Nefazodone
  • Rifampin
  • CYP3A4 inducers: dexamethasone or certain anticonvulsants (phenytoin, phenobarbital, carbamazepine)
  • CYP3A4 inhibitors: ritonavir
Other Interactions
  • Grapefruit juice- Drinking large amounts of grapefruit juice may cause an increase in the concentration of buspirone in your plasma.
During treatment with this medication, you may experience side effects which may go away as your body adjusts to the medication. The most common side effects of buspirone include: dizziness, lightheadedness, drowsiness, diarrhea, nausea, headache, insomnia, nervousness, excitement, and mild congestion.
Buspirone is a prescription medicine used to treat certain anxiety disorders or for the short term relief of anxiety symptoms.
If you miss a dose of buspirone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
Do not abruptly stop taking buspirone without first checking with your healthcare provider, even when you feel better. Abruptly stopping can cause withdrawal symptoms including: vomiting, irritability, dizziness, headaches, sensation of tingling skin, or trouble sleeping.
You may experience some improvement within the first 1-2 weeks of treatment, but may need up to 6-8 weeks to experience the full benefits.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare provider. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If you no longer need your medication, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA Diversion Control Division Lookup to find your nearest drug disposal site.

If no drug take back sites, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  1. Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  2. Place the mixture in a container such as a sealed plastic bag;
  3. Throw away the container in your trash at home; and
  4. Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.