The fresh prince
Aging can feel terrifying. One day you wake up, you look in the mirror, and the man looking back at you looks like an exhausted stranger. This unfortunate moment in a man’s life is the very reason our dermatologists formulated this powerful Anti-Aging Cream. Not only will it help smooth out your wrinkles, but it’ll help repair the damage from the sun and environment. Which means aging might not be so scary after all.
Meet tretinoin, this cream’s key ingredient. Tretinoin not only helps renew and restore your skin’s youthful glow, but it works to increase collagen—that protein that helps keep your skin elastic, firm and ultimately in place.Learn: Common uses of tretinoin (retin-a) cream
As you age, your body produces less and less collagen, and UV exposure can further decrease your collagen levels. This customized formula—which includes a dose of tretinoin—helps your skin produce more collagen to restore your face's buoyant glow. 😇Learn: How tretinoin works
Your doctor will tell you how to use this powerful prescription cream. Since it usually takes some time for results to become noticeable— typically about 3 to 6 months—once you start, don't stop (unless you experience a reaction or your doctor tells you to). Your doctor may recommend you start with just 2 to 3 nights a week, then ramp up to nightly use after your skin adjusts. Be sure to connect with a doctor through our platform if you are experiencing any side effects.Learn: How to use tretinoin for wrinkles and aging
Because this treatment renews your skin's surface, it's normal to see some dry, red or flaky spots. To help with the dry spots, you can use a moisturizer—but be sure it's free of alcohol, benzoyl peroxide, salicylic acid and other exfoliators to avoid extra irritation. Connect with a doctor through our platform if you are concerned about any reaction you're experiencing.Learn: What to expect when using tretinoin for wrinkles
Approved for use in dermatology for more than four decades, tretinoin is one of the most well studied topical retinoids available. Below are some significant studies of tretinoin for wrinkles and sun damage. Read on for evidence showing how tretinoin can help with these common effects of aging.
In this study, researchers assigned 30 patients into two groups, one of which received treatment with tretinoin cream and one of which received a non-therapeutic vehicle cream.
A skin analysis was performed on skin on the forearm after 16 weeks of treatment to assess the effects of tretinoin on photoaging. After 16 weeks, the participants in the tretinoin group showed a “statistically significant improvement” in photoaging.
A second analysis was performed of facial skin, with similar results -- 14 of the 15 participants in the tretinoin group showed an improvement in photoaging, compared to none of the participants in the vehicle group.
Throughout the study, the only reported side effect was irritation of the skin in the group given the tretinoin cream.
This six-month study assessed the performance of tretinoin as an anti-aging treatment. Over the course of six months, participants were given either a .05% tretinoin cream or a non-therapeutic vehicle cream.
After six months, clinical analysis showed a significant improvement in fine and coarse wrinkling, skin hyperpigmentation, looseness and sallowness in the tretinoin group.
The study participants also completed a self-appraisal questionnaire. Participants in the tretinoin group reported a self-perceived improvement in their facial appearance, whereas participants in the non-therapeutic vehicle group did not report any perceived improvement.
In this study, participants were given either .05% tretinoin cream or a placebo and instructed to apply it daily to their facial skin. The study took place over 12 weeks, with a final assessment of results after 12 weeks of treatment.
At the end of the study, participants given the tretinoin cream showed a significant improvement in “fine wrinkling around the eyes, crease lines around the mouth and cheeks, wrinkling on the dorsum of the hands and yellow discoloration.”
In total, 15 of the people in the tretinoin group were assessed as having experienced some skin improvement over the course of the study, compared to just two in the placebo-treated group.
This study also showed an increase in skin thickness after tretinoin treatment, with skin biopsies from the tretinoin group demonstrating a mean increase in epidermal thickness (P = 0.019) that was also visible at a second assessment conducted four weeks after the end of the study.
This 1990 study compared tretinoin cream (.01% for the first month, followed by .025% for the second month and .05% for months three to six) to a non-therapeutic vehicle cream to assess the effects of tretinoin on wrinkles and other signs of aging.
During the six month study, 19.1% of patients withdrew; only 5.6% left the study for reasons related to the treatment.
After six months, silicone skin replica samples taken from the patients revealed a decrease in the width of wrinkles in the tretinoin users, as well as improvements in follicle density and skin texture.
Throughout the study, tretinoin was well tolerated -- 51.4% of study participants had reported an excellent level of tolerability, with 44% reporting good tolerability from the medication.
In this 24-week study, participants were given a tretinoin cream formulation at .05% or .01%, or a non-therapeutic vehicle. In total, 251 people took part in the study, which involved daily use of the cream over a period of 24 weeks.
At the end of the treatment period, 79% of the study participants who received tretinoin .05% had an “overall improvement in photodamaged skin” compared to an improvement in 48% of participants who received the non-therapeutic vehicle cream.
Specifically, people in the tretinoin-treated group showed reductions in fine wrinkling, mottled hyperpigmentation, roughness, and laxity when compared to people given the non-therapeutic vehicle cream.
The researchers observed several side effects during the study -- erythema, skin peeling, and stinging -- but noted that they were mild and well tolerated.
This 1991 study involved 533 subjects at eight different locations in the United States. The study participants were given one of three concentrations of tretinoin cream (.05%, .01% or .001%) or a non-therapeutic vehicle cream.
Skin biopsies were taken from the periorbital (crow’s feet) area of the face at the beginning of the study and after 24 weeks of tretinoin usage.
At the end of the study, the researchers noted four dose-dependent changes in the skin of the tretinoin users: an increase in epidermal thickness, a reduction in melanin content, stratum corneum compaction and an increase in granular layer thickness.
On the whole, the researchers concluded there was “no significant difference between 0.001% tretinoin and the vehicle” and that “no obvious dermal changes were detected in any group.”