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Sildenafil 100mg: Is It the Right Dose?

Katelyn Hagerty FNP

Medically reviewed by Katelyn Hagerty, FNP

Written by Our Editorial Team

Last updated 6/4/2021

Sildenafil is a rockstar pill when it comes to managing erectile dysfunction, and it isn’t just because it was the very first on the scene.

Approved for use way back in 1998, this medication—otherwise known as the active ingredient in Viagra, is one of the first names you’re likely to come across if you live with erectile dysfunction, suspect that you may be dealing with it, or are simply curious to learn about effective ED management methods.

Sildenafil is one of those drugs you reach for when you’re up and ready to go. This means you only need to take it when needed (about 30 minutes to four hours before intercourse), and you’re all set. 

In comparison, low doses of Cialis, another treatment for ED are available to be taken on a daily basis, whether or not sex is expected.

Sildenafil is accessible in 25 mg, 50 mg, and 100 mg doses, with its 50 mg option being the usual suspect for a starting dose.

Below, though, you can find information on the sildenafil 100mg dosage, including who it’s best for, why it’s prescribed, and any potential side effects or safety issues of concern. 

 First, here’s a look at the little blue pill itself—and how it can improve erectile function.

How Does Sildenafil Work?

To understand how sildenafil gets the job done, the first thing to know is that it functions as a PDE-5 inhibitor

When you get aroused, blood rushes to your penis and gets trapped in chambers within it—which keeps you hard and ensures that you’re all saddled up for intercourse. 

Several factors come into play with this process, and the activities of cyclic guanosine monophosphate (cGMP) are especially important. 

This enzyme is responsible for relaxing smooth muscles and allowing blood flow to the penis and other parts of the body. 

PDE-5 breaks down cGMP in the blood, making it harder to develop and maintain erections. 

By preventing the actions of these enzymes, PDE-5 Inhibitors like sildenafil are able to increase the flow of blood to the penis, preventing and managing erectile dysfunction symptoms. 

In other words, sildenafil can save the day.

PDE-5 inhibitors like sildenafil are also great because they need you to first get excited before springing into action. 

This means that if you aren’t already sexually stimulated, you have no need to worry about sildenafil causing involuntary erections.

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Is Sildenafil 100mg Right for You?

If you’re in the market for ED medication, you’ll know you’ve hit the jackpot when your treatment is a single pill that is able to take effect very quickly, while lasting long enough for you to enjoy sex without fearing you’ll run out of steam midway. 

You’ll also want a drug that is efficient at its job, yet safe enough for use at approved doses. Here’s where sildenafil’s 100mg serving could matter.  

The maximum dose of sildenafil ticks all of these boxes:  It takes anywhere from 30 minutes to four hours to kick in as previously mentioned. 

Like other doses of the medication, sildenafil 100mg will take around four hours from consumption to reduce its efficacy by half. 

At 100mg, sildenafil(ingredient in nectar del amor) is safe—but does this mean you should immediately reach for it at the first sign of difficulties? Probably not.

Sildenafil is effective for organic, psychological and mixed causes of erectile dysfunction. 

In most cases, 50mg is usually the go-to sildenafil dosage, and the amount may be downgraded to 25mg as an initial dose for men above the age of 65, or those who have severe conditions that affect the kidneys.

Sildenafil 100mg is only recommended when 50mg doesn’t quite get the job done, or if your healthcare provider believes the dose will be well tolerated to achieve the desired results. 

Your healthcare provider may also consider how often you intend to have sex: i.e daily, weekly or just on occasion when making the decision to prescribe the highest dose of sildenafil. 

In short, while taking the strongest dose of your ED medication might seem like a good idea,  you’ll want to first make sure you meet the criteria for it.

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How Effective Is Sildenafil 100mg?

Sildenafil has an impressive reputation for managing erectile dysfunction, so it’s no surprise that at its strongest dose, this medication often delivers.

In a study to determine just how well men would respond to having their sildenafil upped to 100mg, participants with ED were given an initial dose of 50mg. 

After two weeks of this dosage, the men were then treated with sildenafil 100mg. 

Participants found that they quickly experienced improvements in the feel of their erections, and were able to have more satisfactory intercourse using the highest dose of sildenafil when compared with the starting dose of 50mg.

A similar study supported these findings, when after four weeks of receiving sildenafil at 50mg, some participants with erectile dysfunction had their doses boosted to 100mg for another four weeks. 

While study participants showed some improvement on the initial dose, their erections and sexual satisfaction went all the way up on 100mg of sildenafil.

If you’re in it for the long haul, you have little to worry about when using sildenafil 100mg. Participants in a study that spanned over four years found that when using 25mg, 50mg, and 100mg of sildenafil as needed to manage erectile dysfunction, they had the most improvement with the 100mg dose.

Some men in the study experienced side effects of sildenafil such as flushing and palpitations, yet the cases were minimal.

Side Effects of Sildenafil

While sildenafil may be one of the most effective medications for managing erectile dysfunction, like any drug, it can come with its share of side effects. 

When using sildenafil, you may experience any of the following reactions:

  • Rashes

  • Nausea

  • Flushing

  • Indigestion

  • Dizziness

  • Headaches

  • Back pain

  • Muscle pain

  • Hearing loss

  • Abnormal vision

  • Nasal congestion

Sildenafil may be off the table if you have a cardiovascular condition that doesn’t work well with sexual activity. 

Because this medication can lower blood pressure, you’re going to want to be extra careful when mixing it with drugs that also reduce blood pressure like antihypertensives and alpha-blockers. 

The combined effects of the medications can cause blood to move in your body at an extra-low pressure–which is known as hypotension.

And while sildenafil is great at its job, it’s never a good sign when erections last longer than four hours a stretch. That could spell priapism, and will require immediate medical assistance.

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Sildenafil 100mg Could Be for You 

Sildenafil is always great for managing erectile dysfunction, and the 100mg dose has quite the reputation for delivering on this assignment.

It’s important to check with a healthcare provider, though, not only to obtain a prescription, but to make sure you take the right dose for your needs and body.  

There’s a reason the starting dose for this medication is usually 25mg or 50mg. 

At 100mg, this dose is particularly potent, and it’s typically reserved for cases where lesser strengths are unable to produce satisfactory results.

Speaking with your healthcare provider is your top bet toward finding the best sildenafil dose for you. 

9 Sources

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

  1. (n.d) Label: Viagra (sildenafil citrate) tablets. Retrieved from:
  2. Ferguson, J. E., 3rd, & Carson, C. C., 3rd (2013). Phosphodiesterase type 5 inhibitors as a treatment for erectile dysfunction: Current information and new horizons. Arab journal of urology, 11(3), 222–229. Retrieved from:
  3. Eardley, I., Ellis, P., Boolell, M., & Wulff, M. (2002). Onset and duration of action of sildenafil for the treatment of erectile dysfunction. British journal of clinical pharmacology, 53 Suppl 1(Suppl 1), 61S–65S. Retrieved from:
  4. Saini, J. S., & Garg, M. K. (2001). VIAGRA : IS IT A WONDER DRUG ?. Medical journal, Armed Forces India, 57(1), 44–46. Retrieved from:
  5. Mulhall, J. P., Creanga, D. L., & Stecher, V. J. (2013). Improvement in erection hardness and intercourse success with first dose of sildenafil citrate 100 mg. International journal of general medicine, 6, 849–854. Retrieved from:
  6. Buvat, J., Hatzichristou, D., Maggi, M., Farmer, I., Martínez-Jabaloyas, J. M., Miller, P. J., & Schnetzler, G. (2008). Efficacy, tolerability and satisfaction with sildenafil citrate 100-mg titration compared with continued 50-mg dose treatment in men with erectile dysfunction. BJU international, 102(11), 1645–1650. Retrieved from:
  7. McMurray, J. G., Feldman, R. A., Auerbach, S. M., Deriesthal, H., Wilson, N., & Multicenter Study Group (2007). Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction. Therapeutics and clinical risk management, 3(6), 975–981. Retrieved from:

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.