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Sertraline for Premature Ejaculation: Does it Work?

Sertraline for Premature Ejaculation: Does it Work?

Sertraline is a popular antidepressant—and that’s what it’s generally prescribed for—but did you know it’s also prescribed off-label to treat sexual health issues like premature ejaculation? Sertraline for premature ejaculation isn’t generally something most people think about, but the supporting evidence is there, and you should be aware of it.

Premature ejaculation (PE) is one of the most common sexual dysfunctions, affecting up to 39% of men according to study data. If you’re dealing with premature ejaculation, you’re most certainly not alone. PE affects men of all ages, body types and backgrounds, causing everything from a hit to your confidence to serious, persistent anxiety about your sexual performance.

Luckily, premature ejaculation doesn’t need to be something you’ll live with forever. Today, there are a variety of treatments—from home remedies for premature ejaculation, to a veritable smorgasbord of pills and supplements—available to help mitigate the effects of PE.

Sertraline is one of them.

Below, we’ve explained what sertraline is, how it works and how it can potentially help you avoid premature ejaculation. We’ve also listed several other premature ejaculation treatments that can work alongside or instead of sertraline to help you improve your sexual performance.

What is Sertraline?

Sertraline is an antidepressant that’s part of the selective serotonin reuptake inhibitor (SSRI) class of medication. It’s one of the most widely used antidepressants in the world, with more than 30 million prescriptions in the United States alone.

You might have heard of sertraline before as Zoloft, the original brand name used by Pfizer to market this medication.

Originally developed as an antidepressant, sertraline is used today to treat a variety of health conditions. It’s a common treatment for social anxiety disorder (SAD), obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD).

It’s also prescribed off-label as an effective premature ejaculation treatment. We’ve covered this in greater detail below, along with links to study data on sertraline’s effectiveness as a PE treatment.

Sertraline and Premature Ejaculation

Although sertraline was originally developed as an antidepressant, it also works effectively as a premature ejaculation treatment.

In fact, studies of sertraline show that men affected by premature ejaculation can potentially increase their average intravaginal ejaculation latency time (“IELT,” the amount of time during sex before ejaculation) by a significant amount through regular use of sertraline.

In a 1998 study, 46 men between the ages of 22 and 63 with premature ejaculation were given oral sertraline tablets. The men began the study at a dose of 25mg per day before increasing to 50mg per day by week three and 100mg per day by week six.

At the start of the study, the men had a mean ejaculatory interval of one minute, with a range of zero to five minutes.

With a 25mg daily dose of sertraline, the mean ejaculatory interval increased from one minute to 7.6 minutes, with a range of zero to 20 minutes. With a 50mg dose, the men’s mean ejaculatory interval increased to 13.1 minutes.

With a daily dose of 100mg of sertraline, the men’s mean ejaculatory interval increased to 16.4 minutes. The minimum ejaculatory interval also increased, with a total range of seven minutes to anejaculation (inability to ejaculate).

During the study, side effects were limited. At the full dose of 100mg per day, the most common side effects were dyspepsia (indigestion), feelings of anxiety, transient drowsiness and anorexia, as well as erectile dysfunction and reduced libido.

These side effects were reported by less than 10% of the men who took part in the study, with most participants reporting no side effects from the medication.

Other studies of sertraline show similar results. In a 1999 study, men with premature ejaculaton who used sertraline increased their mean ejaculation latency from 23 +/- 19 seconds before any treatment to 5.9 +/- 4.2 minutes after treatment with 50mg of sertraline per day.

This same study also found that sertraline works as a treatment for premature ejaculation when used on an as-needed basis.

When the men used sertraline as needed on the day of intercouse at a dose of 50 to 100mg, the mean ejaculation latency for the group increased from 23 +/- 19 seconds prior to any treatment to 5.1 +/- 3.8 minutes after two weeks, and 4.5 +/- 2.7 minutes after four weeks.

Both the men and their sexual partners recorded an increase in their sexual satisfaction scores over the course of the study (5 being extremely satisfied, with 0 being extremely unsatisfied).

Their partners recorded a mean sexual satisfaction score of 1.1 +/- 0.7 before treatment, which increased to a mean score of 3.3 +/- 1.2 after four weeks of as-needed sertraline treatment.

The men recorded an improvement in mean sexual satisfaction score from 0.8 +/- 0.8 prior to treatment to 3.4 +/- 1.0 after two weeks of treatment with 50 or 100mg of sertraline as needed and 3.2 +/- 0.7 after four weeks of treatment with 50 or 100mg of sertraline as needed.

Just like in the 1998 study, side effects were rare. One patient experienced excessive delay of ejaculation, with one other patient reporting numbness and two experiencing fatigue.

In short, studies show that using sertraline for premature ejaculation works.

How to Use Sertraline For Premature Ejaculation

As the studies linked above show, sertraline can be used as needed or daily as an effective premature ejaculation treatment.

Like with other medications, there’s no “best” way to use sertraline for PE. The most effective approach is to follow your doctor’s instructions and take your prescribed sertraline dosage as needed or on a daily basis.

Most of the time, it a few weeks for sertraline to become fully effective. In the studies linked above, most men experienced the biggest improvement in ejaculation latency after using sertraline for four weeks.

Does Sertraline Have Side Effects?

Like all SSRIs, sertraline can potentially cause side effects. These side effects are usually mild and only affect a small percentage of men who use sertraline, especially at the mild dose that’s used to treat premature ejaculation.

Our complete guide to sertraline side effects lists all of the common and uncommon side effects of sertraline, with detailed study data on how often each side effect occurs.

Other Ways to Treat Premature Ejaculation

While sertraline is safe, convenient and highly effective, it’s not the only treatment available for premature ejaculation. Other options for treating PE include topical sprays, behavioral therapy, sexual techniques and even medications like sildenafil (the active ingredient in Viagra).

We’ve listed these options below—including some effective home remedies for premature ejaculation—along with other resources to help you learn more about stopping premature ejaculation.

Topical Sprays

Topical sprays containing lidocaine are a popular, effective treatment for increasing ejaculation latency and stopping premature ejaculation.

Lidocaine is a safe, widely used local anaesthetic. If you’ve ever had dental surgery, there’s a good chance your dentist used lidocaine or a similar local anaesthetic to desensitize your gums before the procedure.

Used topically, lidocaine works by making your penis less sensitive to touch. During sex, you’ll feel slightly less, stopping you from ejaculating early due to physical stimulation. You’ll still stay hard and enjoy the experience, just with a slightly reduced level of sensation.

Studies show that lidocaine sprays work well as a treatment for premature ejaculation. In a 2003 study, a topical lidocaine spray increased average intravaginal ejaculation latency time from just 84 seconds to 11 minutes and 21 seconds for men with premature ejaculation.

Interested in learning more about sprays for treating PE? Our guide to lidocaine and premature ejaculation goes into more detail on how lidocaine spray can help you increase your ejaculation latency and enjoy a better, longer-lasting sexual experience.

Erectile Dysfunction Drugs

Interestingly, several medications used to treat erectile dysfunction like Viagra (sildenafil) and Cialis (tadalafil) can also have benefits as treatments for premature ejaculation.

The precise mechanism by which erectile dysfunction drugs treat premature ejaculation isn’t known. However, studies tend to show that men with premature ejaculation who use erectile dysfunction drugs tend to have longer ejaculation times than their peers.

In a 2007 study, researchers noted that sildenafil (the active ingredient in Viagra) produced a larger improvement in PE symptoms than paroxetine, a widely used SSRI. The researchers concluded that sildenafil is “very effective and safe to treat PE.”

Sildenafil, tadalafil and other erectile dysfunction drugs can also shorten the refractory period, potentially improving sexual performance for men who masturbate before sex to reduce their risk of experiencing premature ejaculation.  

Our guide to premature ejaculation pills goes into more detail on how ED drugs like sildenafil can be used to treat premature ejaculation and improve sexual performance.


While medications are usually the most effective way to increase ejaculation time and treat PE, they’re far from the only option.

If you have mild premature ejaculation, you might be able to increase your ejaculation time by practicing the “stop-start” strategy or “squeeze” technique.

Both of these techniques are easy but effective when used properly. The stop-start strategy is exactly what it sounds like—during sex, when you feel yourself about to orgasm, slow down or stop moving completely and give yourself some time to recover, then continue.

The squeeze technique is equally simple—when you feel that you’re approaching orgasm, use your thumb and finger to gently squeeze the area between the shaft and glans of your penis for about 30 seconds. Once you feel relaxed, go back to having sex as normal.

These techniques aren’t 100% effective, meaning there’s a chance you might ejaculate even if you try to use them in time. However, they provide real benefits for many men (according to one study, as much as 65% of men with PE notice benefits from using the stop-start strategy).

Masturbating Before Sex

As simple as it might sound, masturbating shortly before you have sex can be a great way to increase your ejaculation latency and avoid ejaculating too early.

The idea behind this approach is simple. After you orgasm, you’ll start the refractory period—a recovery phase in which you’ll find it more difficult to orgasm again. This means you’ll last find it easier to last longer during sex, improving your sexual performance and satisfaction.

Our guide to stopping premature ejaculation goes into more detail on this technique, as well as other treatments for avoiding PE and improving your sexual performance.

Learn More About Premature Ejaculation

Surprisingly common and easily treatable, premature ejaculation is a condition that affects tens of millions of men every year.

Interested in learning more about treating premature ejaculation? Our Premature Ejaculation 101 guide goes into more detail on why premature ejaculation occurs, how common it really is and what you can do prevent it from affecting your sex life.

Important Safety Information


Do not take Sildenafil (sildenafil citrate) if you:

  • take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension. Your blood pressure could drop to an unsafe level
  • are allergic to sildenafil, as contained in Sildenafil and REVATIO, or any of the ingredients in Sildenafil

    Discuss your health with your doctor to ensure that you are healthy enough for sex. If you experience chest pain, dizziness, or
nausea during sex, seek immediate medical help

    Sildenafil can cause serious side effects. Rarely reported side effects include:

  • an erection that will not go away (priapism). If you have an erection that lasts more than 4 hours, get medical help right away.
If it is not treated right away, priapism can permanently damage your penis
  • sudden vision loss in one or both eyes. Sudden vision loss in one or both eyes can be a sign of a serious eye problem called
non-arteritic anterior ischemic optic neuropathy (NAION). Stop taking Sildenafil and call your healthcare provider right away if you
have any sudden vision loss
  • sudden hearing decrease or hearing loss. Some people may also have ringing in their ears (tinnitus) or dizziness. If you have
these symptoms, stop taking Sildenafil and contact a doctor right away

    Before you take Sildenafil, tell your healthcare provider if you:

  • have or have had heart problems such as a heart attack,
irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
  • have had heart surgery within the last 6 months
  • have pulmonary hypertension
  • have had a stroke
  • have low blood pressure, or high blood pressure that
is not controlled
  • have a deformed penis shape
  • have had an erection that lasted for more than 4 hours
  • have problems with your blood cells such as sickle cell
anemia, multiple myeloma, or leukemia
  • have retinitis pigmentosa, a rare genetic (runs in families)
eye disease
  • have ever had severe vision loss, including an eye problem
called NAION
  • have bleeding problems
  • have or have had stomach ulcers
  • have liver problems
  • have kidney problems or are having kidney dialysis have any other medical conditions

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins,
and herbal supplements.

    Sildenafil may affect the way other medicines work, and other medicines may affect the way Sildenafil works, causing side effects.
Especially tell your healthcare provider if you take any of the following:

  • medicines called nitrates
  • medicines called guanylate cyclase stimulators such as Adempas (riociguat)
  • medicines called alpha-blockers such as Hytrin (terazosin
HCl), Flomax (tamsulosin HCl), Cardura (doxazosin
mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl),
 Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin).
Alpha-blockers are sometimes prescribed for prostate
problems or high blood pressure. In some patients, the use
of Sildenafil with alpha-blockers can lead to a drop in blood pressure or to fainting
  • medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase), or atazanavir sulfate (Reyataz)
  • some types of oral antifungal medicines, such as
 ketoconazole (Nizoral) and itraconazole (Sporanox)
  • some types of antibiotics, such as clarithromycin (Biaxin),
telithromycin (Ketek), or erythromycin
  • other medicines that treat high blood pressure
  • other medicines or treatments for ED
  • Sildenafil contains sildenafil, which is the same medicine found
in another drug called REVATIO. REVATIO is used to treat a
rare disease called pulmonary arterial hypertension (PAH).
 Sildenafil should not be used with REVATIO or with other PAH
treatments containing sildenafil or any other PDE5 inhibitors
(such as Adcirca tadalafil)

    Sildenafil does not protect against sexually transmitted diseases, including HIV.

    The most common side effects of Sildenafil: headache; flushing; upset stomach; abnormal vision, such as changes in color vision
(such as having a blue color tinge) and blurred vision; stuffy or runny nose; back pain; muscle pain; nausea; dizziness; rash.

    Sildenafil (sildenafil citrate) is prescription medicine used to treat erectile dysfunction (ED).

    Sildenafil is not for women or children.