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Can You Take Cialis® in The Morning and Viagra® At Night?

Katelyn Hagerty

Medically reviewed by Katelyn Hagerty, FNP

Written by Our Editorial Team

Last updated 12/9/2022

Erectile dysfunction, or ED, is a common sexual function issue that can take a major toll not just on your ability to engage in sexual activity, but also on your confidence and self-esteem.

If you’ve experienced ED, you know it can cause embarrassing moments and frustration in your intimate life. We put so much emphasis on virility as men that even a single incident of not being able to get it up can cause everything from feelings of shame to depression and anxiety.

ED is a common condition. In fact, an estimated 30 million men are affected by ED in the United States alone.

If you’re one of these men, it can feel tempting to go overboard on treatments and throw almost every imaginable treatment option at ED in order to improve your sexual performance.

For some men, this means taking Viagra® and Cialis® together to treat erectile dysfunction from multiple angles, somewhat like an “insurance policy” against the risk of not being able to get and maintain an erection firm enough for sex. 

So, can you take Cialis in the morning and Viagra at night? Can you mix Viagra and Cialis at the same time? Does taking Cialis and Viagra together work better than using one ED medication?

Although mixing Cialis and Viagra may seem like a good idea in theory, it’s actually a bad choice that can significantly increase your risk of experiencing adverse effects, including some that may seriously affect your health and well-being. 

Below, we’ve explained what Cialis and Viagra are, as well as how they work as medications for erectile dysfunction.

We’ve also discussed the safety risks and potential side effects associated with taking both ED medications together, as well as what you can do to keep yourself safe while using medication to treat erectile dysfunction. 

How Cialis and Viagra Work

Cialis and Viagra are two of the most widely-used medications for treating erectile dysfunction in men. They’re both highly effective treatments that have been in use for decades, with millions of users in the United States alone.

Both Cialis and Viagra belong to a class of medications called PDE5 inhibitors, which reduce the severity of ED by increasing blood flow to the erectile tissue inside your penis.

Cialis contains the active ingredient tadalafil, which lasts for up to 36 hours in your body. Viagra, on the other hand, contains the active ingredient sildenafil, which lasts for around four hours per dose.

These days, both medications are available as highly affordable generics. In fact, we offer both tadalafil and sildenafil as part of our selection of ED medications, following a consultation with a healthcare professional who will determine if a prescription is appropriate. 

Because Cialis and Viagra work by increasing blood flow, they won’t cause erections unless you experience some type of sexual stimulation.

This means that you won’t get random erections from these medications. Instead, you’ll just find it easier to get and stay hard when you’re in the mood for sex.

Thanks to their effects on blood flow, Cialis and Viagra (as well as their generic equivalents) are also used to treat other medical conditions.

For example, Cialis is used to treat benign prostatic hyperplasia (BPH), a type of non-cancerous prostate enlargement that often occurs in men. 

Generic forms of both drugs are also used to treat pulmonary arterial hypertension (PAH), a type of high blood pressure that can affect the blood vessels in your lungs.

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Why You Don’t Need to Take Viagra and Cialis Together

Because Cialis lasts for a long time and Viagra works quickly, many men affected by ED have wondered if they can take Cialis in the morning and Viagra at night to make these medications even more effective at treating erectile dysfunction.

Taking Cialis and Viagra together isn’t a good idea for several reasons. The first is that there’s no high-quality evidence to suggest that these medications improve your erections more when used at the same time than when used on their own.

The second is that by taking both medications at the same time — even taking low-dose Cialis and Viagra together — you can significantly increase your risk of experiencing side effects and drug interactions. 

Before we get into these, let’s get one important thing out of the way: there’s really no need to take more than one ED medication at a time.

Research shows that Viagra and Cialis are both highly effective forms of treatment for erectile dysfunction.

For example, clinical trials show that most men who use Cialis, even at a low dose, experience improvements in their erections. Similarly, research shows that between 63 and 82 percent of men with ED who use Viagra also show improvements.

If you have ED, you’ll likely find it easier to get and maintain an erection with either medication, meaning there’s no need to take both at once. However, it may take some time to find the right dosage for you after you start using either medication as an erectile dysfunction treatment. 

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Side Effects of Taking Viagra and Cialis Together

Cialis and Viagra can both cause side effects. Your risk of developing side effects may become higher if you use both medications at once, and the side effects you experience could be more severe and bothersome.

Common side effects of Viagra include:

  • Headaches

  • Facial flushing

  • Dyspepsia (indigestion)

  • Vision changes (blurred vision and/or changes in color vision)

  • Nasal congestion

  • Myalgia (muscle pain)

  • Back pain

  • Dizziness

  • Nausea

  • Rash

Common side effects of Cialis include:

  • Headaches

  • Dyspepsia (indigestion)

  • Myalgia (muscle aches)

  • Nasal congestion

  • Pain in limbs

  • Back pain

  • Flushing

Both medications can also cause more severe side effects, including sudden loss of vision, loss of hearing or ringing in your ears, dizziness, chest pain, skin rash or peeling, difficulty breathing and/or swallowing, and swelling that affects your face and/or throat.

Both medications can also cause a decline in blood pressure, which may become more severe when they’re used together.

Another potential consequence of taking two ED medications at the same time is priapism — a type of prolonged, painful erection that can persist for several hours and damage the tissue in your penis.

Priapism is a serious medical emergency, and it’s important to seek urgent medication attention if you develop a painful or unusually long-lasting erection after using ED medication.

Another risk of using both medications at the same time is that interactions with other drugs may become more severe and dangerous.

For example, both Viagra and Cialis can interact with prescription nitrates and other medications used to treat high blood pressure and angina. When used together, these medications can lead to a sudden drop in blood pressure that may cause fainting, heart attack or stroke.

Put simply, there are serious risks associated with using Cialis and Viagra together, even if both medications are taken at a low dose. 

Beyond this, there doesn’t appear to be much of a benefit to taking both ED medications at the same time, at least when it comes to erections and sexual performance.

Cialis and Viagra don’t make you get hard on their own, nor do they have any known effects on your sex drive or level of sexual arousal. Instead, both medications work by making it easier for blood to flow to the tissue inside your penis.

This means that you’ll still only get an erection when you feel sexually aroused, even after using either medication.  

As such, it simply isn’t worth dealing with the increased risk of side effects that comes with using both medications together.

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The Bottom Line on Taking Cialis and Viagra Together

Can you take Cialis in the morning and Viagra at night? Doing so isn’t recommended, as taking both medications together will significantly increase your risk of side effects while providing little or no benefit for your erectile function or general sexual performance. 

If you’re prescribed Cialis or Viagra and still find it difficult to get or maintain an erection, it could be a sign that you have an underlying health issue that’s causing your ED.

This could be a psychological issue such as sexual performance anxiety, depression or feelings of guilt about sex. It could also be a habit that affects your sexual health, such as watching porn excessively.

Alternatively, if you simply don’t feel as interested in sex as you used to, you may have an issue such as low testosterone levels

Not only is doubling up on ED pills an ineffective way to treat these issues — it can also put your health and well-being at risk.

These are issues that you’ll want to discuss with your healthcare provider, not treat by doubling up on ED medication. 

If you’re interested in treating erectile dysfunction safely and effectively, you can take part in an online ED consultation to learn more about your options. 

If appropriate, you may receive a prescription for an ED medication such as sildenafil (the active ingredient in Viagra), tadalafil (Cialis) or avanafil (Stendra®).

Don’t despair — there are plenty of options available, and your solution may be as easy as trying a different pill, dropping some bad habits or picking up some good ones. 

6 Sources

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

  1. Definition & Facts for Erectile Dysfunction. (2017, July). Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/definition-facts
  2. Dhaliwal, A. & Gupta, M. (2022, May 20). PDE5 Inhibitors. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK549843/
  3. CIALIS- tadalafil tablet, film coated. (017, May). Retrieved from https://www.accessdata.fda.gov/spl/data/05dbd8b6-1b9d-436a-a67c-8a16713f753f/05dbd8b6-1b9d-436a-a67c-8a16713f753f.xml
  4. VIAGRA- sildenafil citrate tablet, film coated. (2017, August). Retrieved from https://www.accessdata.fda.gov/spl/data/40578e70-350a-4940-9630-55d90989c146/40578e70-350a-4940-9630-55d90989c146.xml
  5. Sildenafil. (2018, January 15). Retrieved from https://medlineplus.gov/druginfo/meds/a699015.html
  6. Tadalafil. (2022, February 15). Retrieved from https://medlineplus.gov/druginfo/meds/a604008.html

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.