Medically reviewed by Kristin Hall, FNP
Written by Our Editorial Team
Last updated 6/07/2019
Erectile dysfunction (ED) medications like sildenafil (main ingredient in Viagra, generic Viagra) and tadalafil have been around for decades, with millions of users and proven safety records. For healthy men without cardiovascular conditions, ED medication is thoroughly tested and widely regarded as completely safe.
However, if you have heart disease, you should consult with your doctor immediately. Don't even think about taking ED medicine with a heart condition if you haven't talked to your doctor first.
ED medication works by increasing your body’s production of nitric oxide, which studies show helps men achieve erections. The downside is nitric oxide can also cause arteries throughout the body to dilate. This can lead to a drop in blood pressure that can cause issues for men with cardiovascular disease.
In this guide, we’ll explain the link between heart disease and erectile dysfunction, how widely used ED medications such as sildenafil and tadalafil can affect the heart, as well as the interactions and effects you should be aware of if you suffer from heart disease.
ED drugs such as sildenafil, tadalafil and vardenafil have a variety of side effects, most of which are relatively minor. Our guide to what you should expect from ED medication goes into greater detail on the most commonly reported side effects of ED medication.
Beyond these side effects, most ED medications can also affect the cardiovascular system through an increase in nitric oxide production.
Nitric oxide is a signaling molecule released by arteries to dilate blood vessels. ED medications work by increasing the body’s production of nitric oxide, which boosts blood flow to areas of the body like the soft tissue of the penis.
The end result is an improved erection, but with some cardiovascular side effects. Because all arteries of the body produce nitric oxide, the effects of drugs like sildenafil and vardenafil aren’t limited to the penis. Instead, all of the body’s blood arteries can dilate.
This results in a drop in blood pressure while the drug is active—for most men, around five to eight mmHg.
In healthy men without heart disease, this drop in blood pressure is rarely an issue. However, if you take nitrates to treat high blood pressure or another cardiovascular condition, the combined effects of these drugs and ED medication can be dangerous.
If you take nitrates to treat heart disease, using ED medication can result in a significant, dangerous drop in blood pressure.
This is because ED medications and nitrates both increase nitric oxide levels and widen arteries to improve blood flow. Combined, the medications can interact and result in dangerous drops in blood pressure of as much as 25–51 mmHG, according to the Harvard study linked above.
Medications that can interact with ED drugs include nitroglycerin, as well as other nitrates such as isosorbide dinitrate and isosorbide mononitrate.
Nitrates that are used recreationally, such as amyl nitrate and amyl nitrite, can also mean trouble for anyone contemplating taking ED medicine with a heart condition, because they too can interact and cause dangerous drops in blood pressure.
In short, if you use nitrates to treat angina, high blood pressure or other cardiovascular health issues, you cannot and should not take ED medication. If you suffer from heart disease and erectile dysfunction and wish to learn more about treatment options, you should speak to your doctor about safe treatments.
Even if you don’t use nitrates, you should be extremely cautious about taking ED medication if you’re affected by heart disease.
The FDA has recommended that men who’ve suffered from strokes, heart attacks and all other heart disturbances exercise caution regarding ED drugs. This includes common conditions such as high blood pressure, which affects almost one in every three American adults.
If you suffer from high blood pressure, heart disease and erectile dysfunction, the best course of action is to talk to your doctor to learn more about treatment options. Your doctor might be able to offer an alternative treatment or reduced dosage medication that’s safe for you to use.
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