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Can Ketoconazole Shampoo Help With Hair Loss?

Can Ketoconazole Shampoo Help With Hair Loss?

Ketoconazole is an antifungal medication that’s widely used to treat skin and nail conditions like candidiasis, ringworm and seborrhoeic dermatitis.

It’s also a common ingredient in many hair loss shampoos and a substance that you’ll often find recommended, usually in the form of Nizoral shampoo, as part of a hair loss prevention stack.

Ketoconazole is scientifically linked to improvements in hair growth, making it worth using as a male pattern baldness treatment. It’s also easy to apply, since all that’s required is a quick wash in the shower once a week.

In this guide, we’ll explain how ketoconazole works to help you prevent hair loss and fuel hair growth, as well as the most effective way to use a ketoconazole shampoo as part of your hair loss prevention stack.

Does Ketoconazole Shampoo Stop Hair Loss?

While there isn’t quite as much scientific data about ketoconazole and hair loss as there is for minoxidil and finasteride, most studies related to ketoconazole and baldness show that it can be effective for improving hair growth.

One study from 1998 compared ketoconazole and minoxidil to see which had the best effects on hair growth. The researchers discovered that 2% ketoconazole shampoo increased the size and proportion of anagen hair follicles at a similar rate to the minoxidil spray.

There are also animal studies showing that regular use of ketoconazole significantly stimulates the rate of hair growth, even in hair follicles that aren’t usually affected by balding (such as the DHT-immune hair follicles on the back of the head).

Right now, there just isn’t enough data to conclusively say that ketoconazole prevents baldness or definitely regrows hair. However, the scientific evidence that’s currently available does show measurable improvements in hair growth when people use a ketoconazole shampoo.

How Does Ketoconazole Help Stop Hair Loss?

While scientific studies show that ketoconazole seems to stimulate hair growth, they’re far less conclusive about how and why it does this.

Male pattern baldness is caused by dihydrotestosterone, or DHT, an androgen that affects the hair follicles in men with a genetic predisposition to baldness. Over time, DHT can cause hair follicles to miniaturize and gradually stop producing new hairs.

Medication like finasteride works by preventing DHT from developing in the first place, stopping any DHT-induced damage to hair follicles. Right now, there’s limited scientific evidence that use of ketoconazole can affect the same hormonal pathways as hair loss drugs like finasteride.

One scientific paper from 2004 presents a hypothesis that ketoconazole can disrupt the DHT pathway, potentially inhibiting DHT and slowing down hair loss. The researchers propose that ketoconazole could potentially be used as an adjunct to finasteride for stronger hair retention.

It’s important to point out that this is only a hypothesis. Right now, there aren’t any conclusive studies showing that ketoconazole has any measurable effect on DHT, even though it’s shown to have some positive effects on hair growth.

Ketoconazole Shampoo Can Also Prevent Dandruff

Since ketoconazole treats seborrhoeic dermatitis, it’s widely used as an anti-dandruff shampoo ingredient. This means that you’ll probably want to consider adding a ketoconazole shampoo to your hair care stack if you’ve noticed dandruff forming on your neck and shoulders.

Ketoconazole isn’t effective against all forms of dandruff, meaning you’ll want to try a variety of options if you have persistent dandruff that just won’t go away. Our post on preventing dandruff shares several treatment options for improving your scalp health.

Should You Use a Ketoconazole Shampoo Like Nizoral?

Ketoconazole shampoos like Nizoral are often touted online as being one of the "big three" hair loss prevention products, the other being finasteride and minoxidil.

While the current studies don’t yet show ketoconazole as being as much of a help for hair loss as finasteride and minoxidil, it could be effective at helping you create a good environment for hair growth. You should note that the studies which reviewed ketoconazole for hair loss used the prescription strength 2% solution. In the US you can buy the 1% solution over the counter but would need a prescription for the 2% ketoconazole shampoo.

If you decide to add an over the counter ketoconazole shampoo to your hair loss prevention regimen, it’s suggested to use it once a week. You can use a gentler DHT blocking shampoo the rest of the week.

It’s important to remember that ketoconazole shampoos probably won’t do as much to stop your hair loss as finasteride. If you’ve noticed hair loss and don’t take finasteride, you should talk to your doctor and see if it could help you prevent further loss and keep the hair you already have.

You can read more about how male pattern baldness happens in our DHT and Male Hair Loss guide, which explains how you can prevent male hormones like DHT from damaging your hair follicles.

This article was reviewed by Ho Anh, MD.

Important Safety Information

IMPORTANT SAFETY INFORMATION

Finasteride is for use by MEN ONLY and should NOT be used by women or children.

Read this Patient Information before you start taking Finasteride and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment.

What is Finasteride?

Finasteride is a prescription medicine used for the treatment of male pattern hair loss (androgenetic alopecia).

It is not known if Finasteride works for a receding hairline on either side of and above your forehead (temporal area).

Finasteride is not for use by women and children.

Who should not take Finasteride?

Do not take Finasteride if you:

  • are pregnant or may become pregnant. Finasteride may harm your unborn baby.
    • Finasteride tablets are coated and will prevent contact with the medicine during handling, as long as the tablets are not broken or crushed. Females who are pregnant or who may become pregnant should not come in contact with broken or crushed Finasteride tablets.
    • If a pregnant woman comes in contact with crushed or broken Finasteride tablets, wash the contact area right away with soap and water. If a woman who is pregnant comes into contact with the active ingredient in Finasteride, a healthcare provider should be consulted. If a woman who is pregnant with a male baby swallows or comes in contact with the medicine in Finasteride, the male baby may be born with sex organs that are not normal.
  • are allergic to any of the ingredients in Finasteride. See the end of this leaflet for a complete list of ingredients in Finasteride.

    What should I tell my healthcare provider before taking Finasteride? Before taking Finasteride, tell your healthcare provider if you:

  • have any other medical conditions, including problems with your prostate or liver

    Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

    Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

    How should I take Finasteride?

  • Take Finasteride exactly as your healthcare provider tells you to take it.
  • You may take Finasteride with or without food.
  • If you forget to take Finasteride, do not take an extra tablet. Just take the next tablet as usual.

    Finasteride will not work faster or better if you take it more than once a day.

    What are the possible side effects of Finasteride?

  • decrease in your blood Prostate Specific Antigen (PSA) levels. Finasteride can affect a blood test called PSA (Prostate-Specific Antigen) for the screening of prostate cancer. If you have a PSA test done you should tell your healthcare provider that you are taking Finasteride because Finasteride decreases PSA levels. Changes in PSA levels will need to be evaluated by your healthcare provider. Any increase in follow-up PSA levels from their lowest point may signal the presence of prostate cancer and should be evaluated, even if the test results are still within the normal range for men not taking Finasteride. You should also tell your healthcare provider if you have not been taking Finasteride as prescribed because this may affect the PSA test results. For more information, talk to your healthcare provider.

  • There may be an increased risk of a more serious form of prostate cancer in men taking finasteride at 5 times the dose of Finasteride.

    The most common side effects of Finasteride include:

  • decrease in sex drive
  • trouble getting or keeping an erection
  • a decrease in the amount of semen

    The following have been reported in general use with Finasteride:

  • breast tenderness and enlargement. Tell your healthcare provider about any changes in your breasts such as lumps, pain or nipple discharge.
  • depression;
  • decrease in sex drive that continued after stopping the medication;
  • allergic reactions including rash, itching, hives and swelling of the lips, tongue, throat, and face;
  • problems with ejaculation that continued after stopping medication;
  • testicular pain;
  • difficulty in achieving an erection that continued after stopping the medication;
  • male infertility and/or poor quality of semen.
  • in rare cases, male breast cancer.

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of Finasteride. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088.

    How should I store Finasteride?

  • Store Finasteride at room temperature between 59˚F to 86˚F (15˚C to 30˚C).
  • Keep Finasteride in a closed container and keep Finasteride tablets dry (protect from moisture).

    Keep Finasteride and all medicines out of the reach of children.

    General information about the safe and effective use of Finasteride.

    Medicines are sometimes prescribed for purposes other than those listed in this Patient Information. Do not use Finasteride for a condition for which it was not prescribed. Do not give Finasteride to other people, even if they have the same symptoms you have. It may harm them.