Medically reviewed by Kristin Hall, FNP
Written by Our Editorial Team
Last updated 6/24/2020
In our guide to the biggest risk factors for erectile dysfunction, we listed a variety of widely used medications. This list included antidepressants, which are used by almost 13 percent of adult men and women in the United States.
As it happens, antidepressants and erectile dysfunction have a very close link that most men may not consider prior to or during treatment.
In fact, antidepressants are one of the classes of medication most closely linked to sexual dysfunction in men.
Some antidepressants, such as SSRIs, have been shown to cause sexual issues for up to 60 percent of patients that take them on a regular basis.
In this guide, we’ll explain how SSRIs and other antidepressants can cause sexual dysfunction such as ED, as well as the treatment options available for those experiencing sexual side effects from prescription antidepressant use.
Not-So-Fun-Fact: Many antidepressants list sexual dysfunction as a side effect. In men, this is most commonly manifested as a reduction in sex drive (decreased libido) and difficulties developing and maintaining an erection.
Some antidepressants can also make it difficult to orgasm, while others, including citalopram, are linked to significant hormonal disruptions and a large reduction in sperm count.
Sexual side effects such as ED are a side effect of almost all antidepressants, including all of the drugs listed below:
So, in short: Yes. Antidepressants and erectile dysfunction pair well together, unfortunately. If you’re prescribed one of these medications and have noticeable sexual side effects such as erectile dysfunction, it could potentially be a side effect of the antidepressant.
Most antidepressants are selective serotonin reuptake inhibitors (SSRIs), a class of drugs that treat depression and anxiety disorders by increasing the amount of serotonin in the body.
Serotonin is a neurotransmitter that contributes to feelings of happiness and wellbeing, making it important in the treatment of depression, anxiety, panic disorders, eating disorders and a variety of other conditions.
One recent study even states that SSRI users notice an impact on the feelings of love and attachment they experience towards their romantic partner.
SSRIs also have a direct effect on many of the hormones that regulate sexual behavior in both men and women.
For example, many SSRIs cause an increase in prolactin — a hormone that can make it more difficult for men to orgasm and is linked to post-coital sleepiness. Animal studies also suggest that SSRIs can reduce testosterone levels, resulting in a weaker libido.
In short, there are numerous ways in which SSRIs and other antidepressants can affect your sex life. From reduced libido to difficulty orgasming, this class of drug is linked to a range of sexual side effects that can differ from person to person.
One study from 1999 involved 14 male patients, all of whom experienced sexual dysfunction from SSRI use. The patients were given 25mg to 100mg tablets of sildenafil, which they took just before sexual activity.
Thirteen out of the 14 patients, all of whom previously reported sexual dysfunction, experienced an improvement after using sildenafil. Most saw a noticeable improvement at the smallest 25mg dose, while others required a 75mg or 100mg dosage for noticeable results.
In short, drugs like sildenafil appear to work very well in treating erectile dysfunction caused by antidepressants.
The link between antidepressants and erectile dysfunction are clear. If you take antidepressants and have erectile dysfunction, it’s important to talk to your healthcare provider before you consider using medication to treat your ED.
Not all antidepressants have the same side effect profile, meaning your healthcare provider may be able to recommend an alternative medication that treats your depression or anxiety symptoms without the same impact on your sexual desire and performance.
Alternatively, your healthcare provider might recommend adjusting your antidepressant dosage, which can—in some cases—reduce or eliminate the sexual side effects caused by the medication.
Finally, there’s the option of using ED drugs like sildenafil, tadalafil or vardenafil. As always, it’s best to discuss this with your healthcare provider to learn more about how these drugs can be used safely in conjunction with your depression or anxiety medication. You may find it's not as simple as asking, "Can you take Viagra with antidepressants?"
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