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Anti-Aging Supplements: Supplements That Work

Kristin Hall, FNP

Medically reviewed by Kristin Hall, FNP

Written by Our Editorial Team

Last updated 1/13/2021

Birthdays are great — staying up until midnight for celebratory calls, unlimited cake, loved ones sharing your most embarrassing throwback photos on social media — there’s everything to love.

But as years progress, you may notice changes when your birth date comes around: feeling too tired to wait up for calls, watching your blood sugar too closely to indulge in cake and … Wow. was this really what you looked like before wrinkles set in?

Aging is a gradual, natural process. While largely above our control, we can steer how quickly, and how well, we age through anti-aging supplements. These supplements may help you stay healthy, and biologically efficient, irrespective of your age

We’ll examine scientifically proven anti-aging supplements to help determine the best options for you. We’ll also be checking out anti-aging supplements for skin to ensure that you look and feel good with the progression of the years.

Best Anti-Aging Supplements

So, you’re looking to get your Benjamin Button on, but you’re not too certain where to begin. All you know is, you'd like to remain healthy and active for as long as possible.

We’ve selected scientifically proven anti-aging supplements to help you decide on the best anti-aging supplements for your health and wellness. They include:

Vitamin D

There’s a lot of good a walk outdoors will do for you, and exposure to Vitamin D is high up on that list.

Vitamin D is derived from the body’s synthesis of UVB rays from sunshine, but it can also be obtained in smaller quantities from food sources. 

This nutrient is necessary for maintaining bone health, preventing osteomalacia and muscle weakness, while also protecting against falls and low impact fractures. Without it, there are increased risks of aging-related diseases like hypertension, diabetes and heart disease.

However, just as the appeal to stay wrapped up in bed gets stronger, and the desire to go outside on walks gets weaker with age — your body’s ability to properly synthesize vitamin D is also affected as you get older.

To make up for any difficulties with synthesizing vitamin D with age, supplements can help to support your body’s supply of the nutrient to make sure you have continued good bone health. Added to this is the fact that vitamin D can promote your body’s immunity.

Vitamin B12

Vitamins really are show-offy, overachievers when it comes to slowing down the aging process. The B12 vitamin is no different. Without this vitamin, loss of neurological function in adults can occur. This can be seen in visual and motor disturbances. A vitamin B12 deficiency can also lead to cognitive impairments like memory loss, disorientation and dementia. 

Synthesizing this vitamin is a complex process that involves the stomach, pancreas and small intestine. This process becomes more difficult with age, requiring the use of supplements to support the body’s vitamin B12 needs.

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Coenzyme Q10

CoQ10 — despite reading like an impenetrable password, makes for one a significant antioxidant. It can prevent the generation of free radicals, as well as the modification of proteins, lipids and DNA.

In addition, CoQ10 improves energy and supports the immune system.

Even more impressive, Coenzyme Q10 has been linked to the possible prevention and treatment of the following conditions: cardiovascular diseases, high blood pressure, some cancers, Parkinson's disease, kidney failure, muscular dystrophy and, very importantly, aging.

An example of how CoQ10 provides support against aging specifically, is its ability to reduce free radicals and to prevent the activation of cells that can cause chronic inflammation — a common age-related issue.

However, CoQ10 levels in the body reduce with age, increasing the chances of inflammation in the body. CoQ10 supplements then become necessary to maintain health and wellness with age


Even though calcium is termed an 'essential nutrient' for the body's inability to produce it, this 'essential' classification is very fitting for the many important roles calcium plays for the body's health and wellness.

Calcium is a nutrient necessary for the formation and metabolism of bone. It is also needed for teeth strength, as well as heart, muscle and nerve function. Calcium even helps to make sure your blood clots properly, anytime you suffer a cut.

Adequate calcium intake can reduce the risk of fractures, osteoporosis and diabetes in some populations. However, with calcium absorption slowing with age, supplements can help to provide the support the nutrient offers to slow down aging.


When was the last time you paid attention to your magnesium intake? If a recent date doesn’t immediately come to mind, or if you weren’t aware you even needed to pay attention to your magnesium intake, then you may want to begin now.

Magnesium is another popular anti-aging supplement for health and wellness. Age-related illnesses like neurodegenerative disease, decreased muscle performance and insulin resistance may have links to low magnesium in your diet.

Incorporating magnesium supplements into your diet may help in keeping these age-related illnesses at bay. Equally important is the fact that magnesium supplements can assist in nerve and muscle function, and they are also important for energy production.


If you’ve ever excused an extra glass of red wine because of how good it is for your heart — you have the antioxidant, resveratrol to thank.

Resveratrol is an antioxidant derived from red wine. It is recognised for its anti-aging properties, and has been linked to cardiovascular benefits, possible advantages for Alzheimer’s disease and may even hold certain anti-cancer abilities. 

However, more research is required to understand the complete benefits of resveratrol.


PQQ or pyrroloquinoline quinone is known to function by attacking free radicals. Though limited research has been carried out on the effects of PQQ, a study carried out on mice revealed that it may be potentially effective in preventing neurodegeneration.

PQQ may also hold some potential in treating heart failure, a condition whose risk of appearance increases from the age of 65 and above.

With mitochondria dysfunction associated with cardiac diseases — heart failure being one of them — the ability of PQQ to prevent mitochondrial degeneration could be promising news for the management of heart issues.

Best Anti-Aging Supplements for Skincare

Your skin isn’t just the largest organ on your body, it is also the loudest broadcaster that you are starting to get on in age. 

A little wrinkle here, some fine lines there, that neck crease you absolutely did not see coming — anti-aging practices become priority when you want to delay the appearance of age on your skin, for as long as possible. Here are some skin anti-aging supplements you should know:

Vitamin C

This vitamin is one of the top-rated anti-aging supplements. Vitamin C can act as a potent antioxidant, offering protection against the sun’s not-so-great-for the-skin, ultraviolet rays. 

It can also promote wound healing and prevent post-inflammatory hyperpigmentation. 

As an added benefit, vitamin C is also useful for promoting collagen production, which is necessary for stimulating skin hydration and elasticity. 

These are important benefits that can help to prevent the obvious aging of the skin.

Vitamin C is so important that we used it as one of the primary ingredients in our Morning Glow Vitamin C Serum.


When your skin has sufficient collagen, it is hydrated, smooth, firm and strong. You’re all of two minutes away from landing a cover deal. 

But when you’re experiencing a collagen deficit — a common occurrence with age — your skin can become lined, wrinkled, thin and dry. It could do with a collagen boost.

Collagen is necessary for maintaining skin structure. As a dietary supplement, it can be found in capsules and collagen peptide powders.

Vitamin A

How’s this to convince you of this vitamin’s abilities as an anti-aging supplement? 

Vitamin A is the first vitamin approved by the Food and Drug Administration (FDA) as an anti-wrinkle agent

This vitamin belongs to the category of retinoids, and is one of the most effective substances for slowing the skin aging process.

Vitamin A supports the daily replacement of skin cells, and ensures that tissues are able to provide a barrier against infection. As a retinoid, this vitamin prevents the loss of water to the atmosphere, and protects collagen against degradation.


Curcumin is an active component of turmeric which has been shown to have anti-inflammatory, antibacterial and antimicrobial properties

It has also been shown to be beneficial for improving the skin, following damages caused by photoaging. Curcumin may also be useful for the deposition of collagen for enhanced wound healing.


A B3 vitamin, nicotinamide (niacinamide), has been linked to improved skin appearance. It helps to prevent the loss of dermal collagen, a known cause of photoaging. 

NAD+ — an essential coenzyme noted for its benefits in various metabolic pathways, has been linked to the process of aging in individuals.

There is growing evidence that a decrease in NAD+ levels contributes to the development of age-associated changes in the body and body function.

Oral supplementation with nicotinamide has been shown to increase NAD+ levels, helping in slowing down the aging process.

Vitamin E

Over the course of life, the skin is exposed to a number of conditions that can damage and rapidly age it. One of these conditions is oxidative stress brought on by continued exposure to UVA and UVB rays. This exposure has been known to cause skin wrinkling, thickening and may even increase the risk of skin cancer. 

Vitamin E supplements help to protect the skin against photoaging, by acting as an antioxidant. It is also useful as an anti-inflammatory agent. 

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In Closing

There are many, many other supplements that may be beneficial for your skin anti-aging mission. They include: selenium which fights aging and helps to prevent aging-related diseases by exercising antioxidant properties. It also prolongs telomere (age biomarker) length, where shorter telomere lengths have been linked to reduced lifespans

Another example is EGCG, a polyphenol found in green tea may improve skin hydration, moisture retention and the management of wrinkle formation.

Amino acids are also important for the repair of damaged skin, and water retention in cell layers

Consulting with a healthcare professional before using any skin supplements, as well as practicing good skincare habits like daily sunscreen use, can be beneficial to your skin anti-aging journey.

Now, we could be wrong, but the chances of continued good health and wellness seem like options you'd like to enjoy as you get older.

Throw in the chance of having well-preserved skin as you enjoy these options, and your best shot could lie with incorporating the right supplements to your lifestyle. 

To get the best benefits however, we advise that you reach out to your healthcare provider or a trusted dermatology practitioner to guide you through the best supplements for your needs.

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.